how to buy propecia quebec next day black subunits indicate statistically significant increase and the white subunits were not detected in the AP-MS experiments. Dark gray subunits were detected but did not show statistically significant differences between the WT and the mutant. Credit: <i>Molecular Brain</i> (2022). DOI: 10.1186/s13041-022-00974-z. https://molecularbrain.biomedcentral.com/articles/10.1186/s13041-022-00974-z” width=”800″ height=”529″>
There’s new hope for the future treatment of some leukodystrophies, neurodegenerative diseases in young children that progressively affect their quality of life, often leading to death before adulthood.
The development stems from the work of Benoit Coulombe, director of the Translational Proteomics Laboratory at the Clinical Research Institute of Montreal (IRCM) and a professor of biochemistry and molecular medicine in the Faculty of Medicine of Université de Montréal.
Published in the journal Molecular Brain, the new research shows that the drug Riluzole, approved by the U.S. Food and Drug Administration to treat certain forms of amyotrophic lateral sclerosis, can at least partially correct the molecular cause of some leukodystrophies.
“Indeed, we have shown that the causative mutations of some leukodystrophies affect the subunits of an important cellular enzyme, RNA polymerase III, preventing its normal assembly—it turned out that Riluzole can counteract this assembly defect,” said Maxime Pinard, the researcher responsible for the project in Coulombe’s lab.
“For diseases as serious and debilitating for patients and their families as leukodystrophies, learning about such advances in knowledge carries a great deal of hope, which IRCM warmly welcomes,” added Dr. Jean-François Côté, the IRCM’s president and scientific director.
Leukodystrophies are rare and almost exclusively genetic diseases characterized by a process of demyelination (damage to the myelin sheath) of the central and peripheral nervous system. The process is primitive in appearance and non-inflammatory and leads to cerebral sclerosis.
“More work is needed to evaluate the effect of Riluzole on patients in order to advance the development of therapeutic avenues for these diseases,” cautioned Marjolaine Verville, co-founder of the Leukodystrophy Foundation.
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