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Unveiling cellular composition and spatial architecture of tumor microenvironment in multiple primary lung cancersvalium vasectomy h KM-plot of the survival curves of TCGA-LUAD patients. The patients were separated into two groups according to whether the expression of RANBP1 (g) and MDH2 (h) was higher than the median level. i. Spatial neighbors (the nearest three circles of spots) of the malignant regions. Colors represent different malignant regions. Sample TM_R_P3 is displayed as one example. j Box plot of the difference of cell compositions between the malignant regions and corresponding spatial neighbors. t test, unpaired. Credit: Cell Death & Disease (2023). DOI: 10.1038/s41419-023-05992-w” width=”800″ height=”530″>
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