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There are several different causes of epididymitis, including sexually transmitted infections (STIs), urinary tract infections (UTIs), prostate enlargement and surgery or other procedures involving the renal system. In some cases, the exact cause of epididymitis is not known, how to buy baclofen paypal payment without prescription which is referred to as idiopathic epididymitis.

Although men of any age can be affected by epididymitis, it is most common in young men aged between 19 and 35 years. Men that engage in sexual activities with multiple partners without the use of a condom are most likely to get the condition. Men with an uncircumcised penis are also at an increased risk.

Sexually Transmitted Infections

The most common causes of epididymitis are sexually transmitted infections (STIs) such as chlamydia and gonorrhea. This is most likely in young men who have unprotected sex, regardless of sexual orientation of the individual. Men who have sexual intercourse with more than one partner without using condoms are at the highest risk of suffering from epididymitis.

Chlamydia infections are estimated to account for more than half of cases of epididymitis in men younger than 35 years old. Other pathogens that may be associated with causing an STI and epididymitis include Neisseria gonorrhea, Treponema pallidum, Gardnerella vaginalis and Trichomonas species.

Urinary Tract Infection

As UTIs are much less common in men than women due to the increased length of the urethra, which makes it more difficult for bacteria to reach the bladder and proliferate to cause an infection. Children or older men with epididymitis are more likely to have the condition caused by a UTI.

E. coli or Pseudomonas bacteria usually cause the infection, as a result of:

  • Enlarged prostate gland pressing on the bladder
  • Insertion of catheter into the urinary system
  • Surgery to the prostate gland, bladder or groin region

Surgery or Trauma to the Groin Region

Epididymitis may also be caused by physical trauma or surgery to the groin region. This includes:

  • Structural abnormalities of the urinary tract
  • Surgery to the prostate, bladder or groin region
  • Urine backflow associated with enlarged prostate or heavy lifting
  • Enlarged prostate pushing against the bladder
  • Groin injury

Recent surgery to the urinary tract may interfere with the structure of the epididymis or the surrounding tissues, resulting in inflammation and symptoms of epididymitis.

Additionally, men with an uncircumcised penis are at a heighten risk of the condition, although this is thought to be linked to an increased susceptibility to infection in the area.


Amiodarone, a medication used to manage arrhythmias or abnormal heart rhythm, has also been associated as a causative factor of epididymitis. Low doses of this medication are not linked to an increased risk of epididymitis, but higher doses may cause the condition.  

Other Health Conditions

There are also several health conditions that are associated with an increased risk of getting epididymitis. These include mumps, tuberculosis (TB) and Behcet’s disease.

Idiopathic Epididymitis

Idiopathic epididymitis is a term used to describe cases of epididymitis when the exact cause is not able to be identified. The condition may result from various circumstances, but there are no obvious risk factors that are likely to be associated with causing the condition.



Further Reading

  • All Epididymitis Content
  • What is Epididymitis?
  • Epididymitis Treatment
  • Epididymitis Diagnosis
  • Epididymitis Symptoms

Last Updated: Aug 23, 2018

Written by

Yolanda Smith

Yolanda graduated with a Bachelor of Pharmacy at the University of South Australia and has experience working in both Australia and Italy. She is passionate about how medicine, diet and lifestyle affect our health and enjoys helping people understand this. In her spare time she loves to explore the world and learn about new cultures and languages.

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